全球突然出现了很多来自宇宙巨大的“入口”，世界一片混乱、陷入危机。这些扭曲现实的入口为何出现，它们的另一端是？

Sarah, a struggling young woman living in Brooklyn, agrees to volunteer as an experimental subject for a pharmaceutical company called Dynamic Health Cure to be the bearer of LEXX and make money to solve her financial troubles and take care of her mother who has Alzheimer's. A nano chip is planted into her cerebral cortex and designed to take control of the body in order to contain diseases as soon as they occur. But when the implant with artificial intelligence turns sinister and orders her to commit crimes, Sarah is plunged into a murderous spiral with only one choice to live or die.

　　當一位精神科醫生研究年輕女孩莫莉的日記，找出她謀殺整個家庭的原因時，他也開始陷入失眠和混亂的狀態，這也是導致她失去理智的原因，一連串不可思議的事件接連發生…