This season began merely two whole weeks after the first season had ended, on April 19, 2008, with the airing of The Elite Guard, and ended on July 5, 2008, with the two-parter, A Bridge Too Close. The season revolved mainly around the Autobots in the aftermath of Megatron's return, trying to restore the city and their image. Meanwhile, Megatron, Lugnut, and Blitzwing have captured Prof. Sumdac in order to build a Space Bridge, hoping to use it to conquer a weakened Cybertron from within. A sub-plot also focuses on Sari as she searches for her father, while learning that there is no record of her existence of any means. Also, Blackarachnia (originally Elita One) has been reduced to a minor recurring character, only appearing in one episode of the entire season (Black Friday).

　　剧情大概：　　一个执行太空任务从宇宙归来的太空舱里的船员被天外异形下了药变成了可怕的怪物，这种异形能寄生到人体使其发生肢体变异。同时期一组洞穴探险员来到城市郊外溶洞探险，没想到此地已经被异形占领，他们只能靠本能来逃脱异形所设下的种种陷阱……（说起山寨，意大利人才应该算是鼻祖吧，就如同这部电影标题一般…不要对这部电影有任何企图，他只会让你变成扑克脸- -）　　血腥度：4　　片中怪物数量：？　　怪物类型：外星生物　　怪物特点：寄生　　怪物必杀技：变形　　怪物恶心度：3

　　It’s 2011 and we’re in Rome. The government is on the verge of collapse, the Vatican is at crisis point and the city’s squares are quite literally on fire. In the middle world, Cinaglia (Filippo Nigro) has tried to pick up where Samurai left off and, together with Badali (Emmanuele Aita), he is still managing the city’s criminal affairs, with the help of Adelaide (Paola Sotgiu) and Angelica (Carlotta Antonelli), who still head up the Anacletis, and Nadia (Federica Sabatini), who helps them to manage Ostia’s town squares.